منابع مشابه
5. Lipinski
Despite over a century of applying organic synthesis to the search for drugs, we are still far from even a cursory examination of the vast number of possible small molecules that could be created. Indeed, a thorough examination of all ‘chemical space’ is practically impossible. Given this, what are the best strategies for identifying small molecules that modulate biological targets? And how mig...
متن کاملWhen do libraries of articulated images obey an isometric embedding?
in image understanding and image coding, it could be useful to ‘learn’ the structure of such image articulation manifolds and to recover the underlying parameters (location, scale, etc.) from unlabeled data. This could be important for recognizing articulated vehicles in target recognition, and for understanding articulated faces in facial recognition. The general problem of learning the shape ...
متن کاملAttraction rules: germ cell migration in zebrafish.
The migration of zebrafish primordial germ cell towards the region where the gonad develops is guided by the chemokine SDF-1a. Recent studies show that soon after their specification, the cells undergo a series of morphological alterations before they become motile and are able to respond to attractive cues. As migratory cells, primordial germ cells move towards their target while correcting th...
متن کاملSpecialization and the Volume of Trade: Do the Data Obey the Laws?
The core subjects of trade theory are the pattern and volume of trade: which goods are traded by which countries, and how much of those goods are traded. The first part of this paper discusses evidence on comparative advantage, with an emphasis on carefully connecting theoretical models with data analyses. The second part of the paper considers the theoretical foundations of the gravity model, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2019
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.9b00063